Abstract Background Heyde’s syndrome is the association of severe aortic stenosis with episodes of gastrointestinal bleeding due to angiodysplastic lesion. Little is known about the factors associated with new episodes of bleeding and long-term outcomes. Furthermore, most data are restricted to case reports and small case series. Objective To assess the clinical, laboratory and echocardiography profile of patients with Heyde’s syndrome who underwent valve intervention or drug therapy. Methods Prospective cohort of 24 consecutive patients from 2005 to 2018. Clinical, […]

Introduction Aortic Stenosis (AoS) is the valvular pathology most frequently acquired in developed countries, present in 4% of individuals over 85 years of age. Patients with severe AoS may have comorbidities, presenting greater risk of thrombotic and bleeding events. Heyde’s Syndrome was described in 1958 by E. C. Heyde as he observed the relation between aortic valve stenosis and gastrointestinal bleeding. In 1992, Warkentin et al. observed the loss of the largest Willebrand factor multimers, characterizing the Acquired type 2A, […]