A monthly publication of the Brazilian Society of Cardiology and considered the main channel for the promotion of Brazilian cardiovascular research.
ISSN 0066-782X
eISSN 1678-4170
Leonardo Rufino Garcia
, André Monti Garzesi, Flávio de Souza Brito
, Marcello Laneza Felicio, Matheus Bertanha
Leonardo Rufino Garcia
, André Monti Garzesi, Flávio de Souza Brito
, Marcello Laneza Felicio, Matheus Bertanha
Cardiovascular diseases are currently the main causes of morbidity and mortality in Brazil and worldwide., Its treatment is multimodal and has as one of its targets the fight against the progression of its major pathophysiological substrate, atherosclerosis. Lifestyle changes, prescription and use of antiplatelet agents, anticoagulants, and hypolipidemic agents, treatment of comorbidities such as systemic arterial hypertension and diabetes mellitus, and even revascularization of target organs lato sensu are important in controlling its clinical evolution. However, many patients still have […]
Keywords: Biocompatible Materials; Blood Vessels; Cardiovascular Diseases; Cell Nucleous (Scaffold; Mortality; Stem Cells; Tissue Engineering, Bioengineering/trends
Tarley Santos Oliveira, Igor Smirnow
, Kadija Mohamed Santee, Maria Angelica Miglino
, Rodrigo da Silva Nunes Barreto
Tarley Santos Oliveira, Igor Smirnow
, Kadija Mohamed Santee, Maria Angelica Miglino
, Rodrigo da Silva Nunes Barreto
Background Objectives The present project aims to achieve the artificial development of blood vessels through the recellularization of vascular scaffolds derived from bovine placental vessels. Methods The chorioallantoic surface of the bovine placenta was used to produce decellularized biomaterials. For recellularization, 2.5 x 104 endothelial cells were seeded above each decellularized vessel fragment during three or seven days, when culture were interrupted, and the fragments were fixed for cell attachment analysis. Decellularized and recellularized biomaterials were evaluated by basic histology, […]
Keywords: Bioengineering; Blood Vessels; Decellularized Extracellular Matrix
Leonardo Rufino Garcia
, André Monti Garzesi, Flávio de Souza Brito
, Marcello Laneza Felicio, Matheus Bertanha
Leonardo Rufino Garcia
, André Monti Garzesi, Flávio de Souza Brito
, Marcello Laneza Felicio, Matheus Bertanha
Background Objectives The present project aims to achieve the artificial development of blood vessels through the recellularization of vascular scaffolds derived from bovine placental vessels. Methods The chorioallantoic surface of the bovine placenta was used to produce decellularized biomaterials. For recellularization, 2.5 x 104 endothelial cells were seeded above each decellularized vessel fragment during three or seven days, when culture were interrupted, and the fragments were fixed for cell attachment analysis. Decellularized and recellularized biomaterials were evaluated by basic histology, […]
Keywords: Biocompatible Materials; Blood Vessels; Cardiovascular Diseases; Cell Nucleous (Scaffold; Mortality; Stem Cells; Tissue Engineering, Bioengineering/trends