Dear Editor, I have read with great interest the article entitled “Major Depression and Acute Coronary Syndrome-Related Factors” by Figueiredo et al., recently published in journal. The investigators found a 23% prevalence of patients with acute coronary syndrome (ACS) meeting the diagnostic criteria for major depressive disorder (MDD). Women were more susceptible to develop MDD in the sample group of ACS patients, with a three-and-a-half-time greater likelihood than men. […]

Abstract Background: Depressive symptoms are independently associated with an increased risk of cardiovascular disease (CVD) among individuals with non-diagnosed CVD. The mechanisms underlying this association, however, remain unclear. Inflammation has been indicated as a possible mechanistic link between depression and CVD. Objectives: This study evaluated the association between persistent depressive symptoms and the onset of low-grade inflammation. Methods: From a database of 1,508 young (mean age: 41 years) individuals with no CVD diagnosis who underwent at least two routine health […]