HDL: Basic Functions and Cardiovascular Controversies High-density lipoproteins (HDL) are a heterogeneous group of particles whose primary function is to promote reverse cholesterol transport. Evidence generated over decades has taught us that having low plasma concentrations of HDL-cholesterol (HDL-C) does not seem to be healthy. Also in 1964, Kannel et al. demonstrated – through an analysis of the Framingham cohort – a strong inverse relationship between plasma levels of HDL-C and atherosclerotic cardiovascular disease. However, this paradigm has changed in […]