Lipids and cardiovascular disease (CVD) Lipid metabolism involves a wide range of complex pathways that play key roles in both normal physiology and disease. Lipids are essential for maintaining cell membrane integrity and supporting energy balance and metabolic homeostasis. Among them, cholesterol has drawn particular attention for its strong association with CVD.– While cholesterol is vital for several physiological functions — such as those related to nervous system structure and steroid hormone production — its role in the development of […]

Abstract Background Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are believed to play key roles in the pathophysiology of coronary slow flow (CSF). Objectives This study aimed to explore the complex biological networks involved in CSF using whole-transcriptome sequencing, with the goal of identifying potential diagnostic biomarkers and therapeutic targets. Methods Whole-transcriptome sequencing was performed on samples from three patients with CSF and three matched control subjects. A p-value < 0.05 was considered statistically significant. Results A total of 854 [...]

Abstract Background Saphenous vein graft (SVG) patency remains a challenge in cases of coronary artery disease following coronary artery bypass grafting (CABG) surgery. The Naples prognostic score (NPS) constitutes a novel scoring system designed to assess both nutritional status and inflammation. Objectives Our study aimed to explore the association between the NPS and SVG disease in patients with a previous history of CABG surgery. Methods A total of 702 patients who had undergone CABG surgery and underwent coronary angiography were […]

Abstract Background Increased oxygen tension and decreased prostaglandin levels cause ductal closure. The diagnostic role of systemic inflammatory indices in hemodynamically significant ductus arteriosus (hsPDA) in premature infants is unknown. Objectives We aimed to evaluate the role of systemic inflammatory indices in the predictivity of hsPDA. Methods Premature infants with gestational weeks (GW) of

Abstract Background: As the predominant leisure-time sedentary behavior, television viewing was documented to increase cardiovascular diseases in observational studies, yet the causal relationship and potential mechanisms remain to be determined. Objectives: To systematically investigate the causal relationship between television viewing time, cardiovascular diseases, and potential mechanisms. Methods: We conducted a two-sample Mendelian randomization (MR) analysis to estimate causal associations with cardiovascular diseases and biomarkers of cardiometabolic risk. The random inverse-variance weighted method was used as the primary estimate. To account […]

Abstract Background Atrial fibrillation (AF) burden is defined as the proportion of time the patient remains in AF over a given period of time; thus, it is theoretically highest in permanent AF and lowest in paroxysmal AF. Inflammation is associated with the initiation and maintenance of AF. However, the relationship between systemic immune-inflammation index (SII) and AF burden is unknown. Objective In the present study, we investigated the relationship between SII and AF burden. Methods The present study is a […]