Heart failure (HF) with reduced ejection fraction (HFrEF) has increased significantly in the last three decades and is associated with high morbidity and mortality. In patients with HF, exercise intolerance suggested by dyspnea or fatigue during exertion is the hallmark of the disease. Additionally, health-related quality of life is known to be markedly reduced in HFrEF patients. The severity of this exercise limitation and low quality of life has been shown to correlate to worse prognosis. For this functional and […]