ACE2, SARS-CoV-2 Infection and Aging Abnormalities induced by aging in metabolic pathways may partly explain the higher rate of COVID-19 morbidity and mortality in elderly patients. These include those belonging to the renin-angiotensin system (RAS), given the crucial role that this system plays both in viral transmissibility and in the pathogenesis of acute lung injury and its most severe form: acute respiratory distress syndrome (ARDS). ACE2 is known to act as a receptor for SARS-CoV-2 1 structural protein S (spike), […]