Atherosclerotic cardiovascular disease (ASCVD) is a systemic disease initiated by an endothelial influx of lipid particles, including low-density lipoproteins (LDL), with subsequent endothelial activation via local recruitment of inflammatory cells. This local process – elicited by age-determined exposure to genetic, environmental, and lifestyle ASCVD risk factors – is the first step of a process that will lead to a chronic, low-grade systemic inflammatory state. Prolonged exposure of the endothelium to ASCVD risk factors and this inflammatory state will increase the […]