Dear Editor, I read with interest the article published by Trombetta et al. In this sense, the importance of disseminating new markers in cardiovascular disease is increasingly known. I bring to the discussion a protein called growth factor / differential 15 (GDF-15) that was first identified as cytokine 1 or MIC-1 of the TGF-beta family, it has pleiotropic effects depending on the model being studied. The interesting thing about this discussion is the interface with which the Brain-derived neurotrophic factor […]

Abstract Cardiovascular disease (CVD) is currently the leading cause of death in Brazil and worldwide. In 2016, CVD accounted for more than 17 million deaths, representing 31% of all deaths globally. Molecular and genetic mechanisms may be involved in vascular protection and should be considered in new therapeutic approaches. In this sense, recent studies have reported that brain-derived neurotrophic factor (BDNF) is reduced in individuals predisposed to develop CVD, and that aerobic physical training increases the amounts of circulating BDNF. […]