Mendelian Randomization (MR) is a powerful statistical tool to infer a causal relationship between the presence of genetic variants and different traits and phenotypes., It is particularly useful when trying to elucidate causal relationships between exposures and outcomes based on observational data. This method bases itself on the principle of randomness of how genetic variants might segregate during the process of meiosis, the Mendelian principle of independent assortment. Since past decades, as our knowledge about the genetic architecture of human […]

The prevalence of diabetes mellitus (DM) has grown in recent decades. Risk factors for developing DM have been well established in clinical studies. Among these, sedentary lifestyles, aging and obesity stand out. DM, defined by increased plasma glucose concentration, is commonly accompanied by cardiovascular alterations such as hypertension, coronary disease, heart failure, and cardiac autonomic neuropathy. As cardiovascular diseases are currently the main causes of death and morbidity, studies aimed at better understanding the pathophysiological mechanisms inherent in DM are […]

Arterial hypertension is highly prevalent in developed and developing countries. Together with high blood glucose levels, hyperlipidemia, overweight and obesity, it is considered a consequence of behavioral risk factors such as physical inactivity, tobacco use, harmful alcohol use and inadequate diets. The cause of arterial hypertension in most of the cases (over 90%) is unknown. The activation of the sympathetic nervous system, the renin-angiotensin-aldosterone system and an abnormal pressure-natriuresis curve play an important role in the pathophysiology of hypertension. Oxidative […]