Introduction Aortic Stenosis (AoS) is the valvular pathology most frequently acquired in developed countries, present in 4% of individuals over 85 years of age. Patients with severe AoS may have comorbidities, presenting greater risk of thrombotic and bleeding events. Heyde’s Syndrome was described in 1958 by E. C. Heyde as he observed the relation between aortic valve stenosis and gastrointestinal bleeding. In 1992, Warkentin et al. observed the loss of the largest Willebrand factor multimers, characterizing the Acquired type 2A, […]