Arq. Bras. Cardiol. 2023; 120(9): e20230050
Association between Morning Surge and Left Ventricular Hypertrophy in Obese Hypertensive Patients
Natascha Gonçalves Francisco Palmeira
, Henrique Tria Bianco
, Maria Teresa Nogueira Bombig
, Fernando Focaccia Povoa
, Francisco A. H. Fonseca
, Maria Cristina Izar
, José Marcos Thalenberg, Braulio Luna Filho, Fabiane Marui, Simone Matheus Fischer, Celso Amodeo, Dilma do Socorro Moraes de Souza, Rui Povoa
This Original Article is referred by the Short Editorial "Morning Surge Blood Pressure and Obesity in Hypertensive Patients".
Introduction
Adult overweight and obesity are associated with reduced life expectancy and increased premature death. Several interrelated mechanisms play an important role in the development of arterial hypertension in obesity, often contributing to target organ damage, including cardiovascular diseases and chronic kidney disease. Obesity-related comorbidities are facilitated by and contribute to a high prevalence of arterial hypertension in the obese population,, by mechanisms including insulin resistance, inflammation, oxidative stress, autonomous nervous system, and activity of the renin-angiotensin-aldosterone system (RAAS).–
In addition, obesity may cause structural changes in the heart, including increased left atrial volume and left ventricular hypertrophy (LVH), which are associated with systolic and diastolic dysfunction. The increase in body weight triggers mechanisms that increase blood pressure (BP), and BP variations in obese hypertensive subjects increase the risk of cardiovascular events.,
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