Chagas disease (CD) was discovered in 1909 by the Brazilian physician Carlos Chagas, who described the etiological agent – a flagellated protozoan named Trypanosoma cruzi ( T. cruzi ) – its morphological features and transmission and life cycle, as well as clinical manifestations of the disease. Although triatomine insects are the primary transmission vectors of CD, the oral route through contaminated food has been considered the main transmission path in the Brazilian Amazon.
The disease presents two clinical phases: an acute infection, mostly symptomatic with high parasitemia, and a chronic infection divided into asymptomatic indeterminate form or symptomatic (digestive or cardiac) form.
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Chagas Cardiomyopathy in the Brazilian Amazon Region: Low Prevalence or Underdiagnosis?
OrtizJV, CouceiroKN, DoriaSS, SousaDRT, SilveiraHMC, Kesper JuniorN, GuerraMGVB, et al. Chagas Cardiomyopathy in the Brazilian Amazon Region: Low Prevalence or Underdiagnosis?. Arq. Bras. Cardiol. 2021;117(4):770-4.
Ortiz,Jessica Vanina; Couceiro,Katia do Nascimento; Doria,Susan Smith; Sousa,Débora Raysa Teixeira de; Silveira,Henrique Manuel Condinho da; Kesper Junior,Norival; Guerra,Maria das Graças Vale Barbosa; Guerra,Jorge Augusto de Oliveira; Barbosa-Ferreira,João Marcos Bemfica. Chagas Cardiomyopathy in the Brazilian Amazon Region: Low Prevalence or Underdiagnosis?. Arq. Bras. Cardiol., v. 117, n. 4, p. 770-774, Oct. 2021.
Ortiz,J.V., Couceiro,K.N., Doria,S.S., Sousa,D.R.T. , Silveira,H.M.C. , Kesper Junior,N., Guerra,M.G.V.B., Guerra,J.A.O., & Barbosa-Ferreira,J.M.B. (2021). Chagas Cardiomyopathy in the Brazilian Amazon Region: Low Prevalence or Underdiagnosis?. Arq. Bras. Cardiol.,117(4), 770-774.
Ortiz,Jessica Vanina and Couceiro,Katia do Nascimento and Doria,Susan Smith and Sousa,Débora Raysa Teixeira de and Silveira,Henrique Manuel Condinho da and Kesper Junior,Norival and Guerra,Maria das Graças Vale Barbosa and Guerra,Jorge Augusto de Oliveira and Barbosa-Ferreira,João Marcos Bemfica. Chagas Cardiomyopathy in the Brazilian Amazon Region: Low Prevalence or Underdiagnosis?. Arq. Bras. Cardiol. [online]. 2021, vol. 117, n. 4, [cited 2025-09-07], pp.770-774. Available from: <https://abccardiol.org/en/article/chagas-cardiomyopathy-in-the-brazilian-amazon-region-low-prevalence-or-underdiagnosis/>. ISSN 0066-782X.
Figure 1
– Phylogenetic position of Trypanosoma cruzi in samples 006 and 012 based on the cytochrome oxidase subunit II gene sequences.