Arq. Bras. Cardiol. 2022; 118(6): 1049-1058

Chemotherapy-induced Cardiac¹⁸F-FDG Uptake in Patients with Lymphoma: An Early Metabolic Index of Cardiotoxicity?

Mayara L. C. Dourado, Luca T. Dompieri , Glauber M. Leitão, Felipe A. Mourato, Renata G. G. Santos, Paulo J Almeida Filho , Brivaldo Markman Filho , Marcelo D. T. Melo , Simone C. S. Brandão

DOI: 10.36660/abc.20210463

This Original Article is referred by the Short Editorial "Precision Medicine: Can 18F-FDG PET Detect Cardiotoxicity Phenotypes?".

Abstract

Background

It is uncertain whether myocardial fluorodeoxyglucose uptake occurs solely due to physiological features or if it represents a metabolic disarrangement under chemotherapy.

Objective

To investigate the chemotherapy effects on the heart of patients with lymphoma by positron emission tomography associated with computed tomography scans (PET/CT) with 2-deoxy-2[18F] fluoro-D-glucose (¹⁸F-FDG PET/CT) before, during and/or after chemotherapy.

Methods

Seventy patients with lymphoma submitted to¹⁸F-FDG PET/CT were retrospectively analyzed. The level of significance was 5%.¹⁸F-FDG cardiac uptake was assessed by three measurements: left ventricular maximum standardized uptake value (SUVmax), heart to blood pool (aorta) ratio, and heart to liver ratio in all the exams. Body weight, fasting blood sugar, post-injection time, and the injected dose of¹⁸F-FDG between the scans were also compared.

Results

Mean age was 50.4 ± 20.1 years and 50% was female. The analysis was carried out in two groups: baseline vs. interim PET/CT, and baseline vs. post-therapy PET/CT. There was no significant difference in clinical variables or protocol scans variables. We observed an increase in left ventricular (LV) SUVmax from 3.5±1.9 (baseline) to 5.6±4.0 (interim), p=0.01, and from 4.0±2.2 (baseline) to 6.1±4.2 (post-therapy), p<0.001. A percentage increase ≥30% of LV SUVmax occurred in more than half of the sample. The rise of cardiac SUV was accompanied by an increase in LV SUVmax/Aorta SUVmax and LV SUVmean/Liver SUVmean ratios.

Conclusion

This study showed a clear increase in cardiac¹⁸F-FDG uptake in patients with lymphoma during and/or after chemotherapy. The literature corroborates with these findings and suggests that¹⁸F-FDG PET/CT is a sensitive and reliable imaging exam to detect early metabolic signs of cardiotoxicity.