Arq. Bras. Cardiol. 2018; 110(3): 292-294
Propafenone Overdose: From Cardiogenic Shock to Brugada Pattern
DOI: 10.5935/abc.20180033
Introduction
Propafenone is a class IC antiarrhythmic drug used in the treatment of ventricular and supraventricular arrhythmias.– It is primarily a potent sodium channel blocker, yet also exhibits beta-blocking and calcium channel blocking activity.,, Propafenone is able to induce important ECG changes, namely prolongation of the PR interval, bundle branch block, wide QRS and QT intervals, as well as ventricular tachycardia or bradycardia., It may be associated with significant proarrhythmogenic effects, even at therapeutic doses. A fatal overdose on propafenone is usually attributed to conduction abnormalities, leading to asystole or electromechanical dissociation. The authors describe two clinical cases of propafenone intoxication with life-threatening ECG changes, but with a favorable final outcome.
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