I read with interest the article published by Costa et al.1 The use of statins in cardiometabolic protection promoted by physical training of moderate-intensity in an aquatic environment has been little studied, mainly from the clinical point of view. However, as described by Costa et al.,1 strength training in an aquatic environment combined with statins has been an effective increase in promoting metabolic adaptations and a reduction in lipid levels. The prognostic predictors associated with the risk of death from cardiovascular disease were measured in the three groups: aquatic training (AT), strength training (ST) and control group (CG). However, a healthy control group was not added to the study, and therefore the statistical power of the test could have been greater. According to the analysis of the body mass index (BMI) of the group (CG), the participants were obese, which was not explained in the inclusion criteria. In addition, there was no homogeneity in the number of individuals on medication (MED) and not on medication (NMED). If related to other variables, the aerobic training intensity indicator may add new questions and lines of thought and research. The effect of statins has been investigated on skeletal muscle function, performance and functional capacity of athletes in different sports and intensity modalities.2 , 3 A randomized, double-blind study showed the protective effect of a statin in reducing the levels of pro-inflammatory cytokines with an increase in the mean concentrations of creatine phosphokinase (PCK); this enzyme plays an important regulatory role in intracellular metabolism, in contractile tissues, in skeletal striated muscles, heart tissue and brain.4 Therefore, in the study by Costa et al.,1 the conclusions respond to the proposed objective, and its theoretical foundations are in line with the question and hypothesis of the study.