Arq. Bras. Cardiol. 2025; 122(7): e20240207
Whipple’s Disease as a Differential Diagnosis of Blood Culture-Negative Endocarditis: A Case Report
Carolina Kuchenbecker Soares
, Rafaela Clara Resende da Silva, Geraldo Brasileiro Filho, Claudio Leo Gelape, Jésus Faria Rosa Júnior, Luiz Guilherme Passaglia
Abstract
Whipple’s endocarditis is a rare infectious condition caused by the bacterium Tropheryma whipplei. Although its systemic form is the most widely recognized, the infection exhibits a broad spectrum of extraintestinal manifestations, with blood culture-negative infective endocarditis being the most common form of cardiac involvement. The case presented in this study underscores the importance of clinical investigation for accurate diagnosis and the application of appropriate treatment.
Keywords: Bacterial Endocarditis; Stroke; Whipple Disease
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