Abstract Background Previous studies have been inconsistent in demonstrating beneficial cardiovascular effects of vitamin D supplementation. Objective To evaluate the effects of vitamin D3 supplementation on central hemodynamic parameters and autonomic activity in obese/overweight individuals with low vitamin D levels (

Abstract Background: Early reperfusion therapy is acknowledged as the most effective approach for reducing case fatality rates in patients with ST-segment elevation myocardial infarction (STEMI). Objective: Estimate the clinical and economic consequences of delaying reperfusion in patients with STEMI. Methods: This retrospective cohort study evaluated mortality rates and the total expenses incurred by delaying reperfusion therapy among 2622 individuals with STEMI. Costs of in-hospital care and lost productivity due to death or disability were estimated from the perspective of the […]

Abstract Background: Visceral adipose tissue (VAT) may be a specific modifiable contributor to body composition-related autonomic impairment. Objectives: To compare heart rate variability (HRV) between groups stratified by visceral fat rating (VFR) and compare associations between HRV and body composition metrics. Methods: A cross-sectional study was conducted on healthy men (n=99,age=37.8±13.4 years, body mass index [BMI]=26.9±4.6 kg/m2). HRV was derived from 5-minute electrocardiographic recordings. Body composition (body fat percentage, VFR, and muscle mass to visceral fat ratio [MMVFR]) was estimated […]

Abstract Background: The foramen ovale remains patent in about 25% of the adult population. In adult life, thrombi form in the venous circulation and can cross the interatrial septum and trigger an ischemic stroke – called paradoxical embolism. The treatment can be performed through percutaneous closure of the patent foramen ovale (PFO), but still rarely performed in Brazil because it is not available in the public health care. Objectives: To evaluate the reproducibility of clinical trial results in real-life studies […]

Introdução Pacientes com infarto do miocárdio com artérias coronárias não obstrutivas (MINOCA) representam 6% a 14% de todos aqueles com infarto agudo do miocárdio (IAM).– O diagnóstico de MINOCA depende da presença de IAM clínico e da ausência de doença arterial coronariana obstrutiva (DAC). Na verdade, MINOCA é inicialmente considerado um diagnóstico válido durante a angiografia até que outras possíveis causas de elevação da troponina sejam excluídas. As causas subjacentes podem ser condições coronarianas ou não coronarianas, incluindo doenças cardíacas […]

Introdução A estenose aórtica degenerativa afeta atualmente 2% a 5% dos adultos com mais de 65 anos, tendo se tornado um problema de saúde pública mundial nas últimas décadas. No Brasil, a prevalência de doença valvar aórtica calcificada aumentou 201,8% de 1990 para 2019, refletindo o envelhecimento da população.O implante valvar aórtico transcateter (TAVI) surgiu como opção para reduzir a mortalidade dos pacientes portadores de estenose aórtica inoperáveis e de alto risco cirúrgico.– Embora diversos estudos clínicos tenham tido importante […]

Abstract Background Transcatheter aortic valve implantation (TAVI) has established itself as the preferential strategy to approach severe aortic stenosis. Information on procedural improvements and nationwide results obtained with the technique throughout the past decade are unknown. Objectives To assess the temporal variation of the demographic profile, procedural characteristics, and in-hospital outcomes of patients undergoing TAVI procedures at the Rede D’Or São Luiz. Methods Observational registry comprising 29 national institutions, comparing the characteristics of the TAVI procedures performed from 2012 to […]

Abstract In coronary artery bypass grafting (CABG) the use of the internal thoracic artery (ITA), is a Class I indication for the left anterior descending (LAD) artery. Atherosclerosis is a systemic disease, and peripheral arterial disease (PAD) is an important complicator of CABG, present in about one-third of the patients with coronary disease. In Leriche Syndrome, ITA can be the source of collateral circulation for arteries below the level of occlusion. Its inadvertent use can lead to serious ischemic complications […]

Abstract Background Residual venous congestion is a major contributor to readmission of patients with heart failure, and the venous excess ultrasound (VExUS) score is a potentially useful tool to evaluate systemic congestion. Objectives To investigate the association between VExUS score before hospital discharge among patients with heart failure and the risk of readmission due to acute decompensated heart failure (ADHF) within 90 days after discharge. Methods This prospective cohort study enrolled adults with signs and symptoms of ADHF, left ventricular […]

Abstract Background: The introduction of anthracyclines in the treatment of children and adolescents with cancer has promoted a significant increase in survival, but also in morbidity and mortality rates due to cardiovascular (CV) complications. Objectives: To determine the cardiovascular profile of pediatric patients treated with anthracyclines at a cancer center in Brazil and the incidence of CV complications. Methods: The following data were collected from the medical records of patients of both sexes, aged younger than 19 years – frequency […]

Abstract Background: Heart failure (HF) contributes to a high burden of hospitalization, and its form of presentation is associated with disease prognosis. Objectives: To describe the association of hemodynamic profile of acute HF patients at hospital admission, based on congestion (wet/dry) and perfusion (cold/warm), with mortality, hospital length of stay and risk of readmission. Methods: Cohort study, with patients participating in the “Best Practice in Cardiology” program, admitted for acute HF in Brazilian public hospitals between March 2016 and December […]

Introduction Patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) account for 6% to 14% of patients of all those with acute myocardial infarction (AMI).– The diagnosis of MINOCA is dependent on the presence of clinical acute MI and the absence of obstructive coronary artery disease (CAD). Actually, MINOCA is initially considered a valid diagnosis during angiography until other possible causes of troponin elevation are excluded. The underlying causes may be coronary conditions or noncoronary conditions including cardiac or noncardiac […]

Introduction Degenerative aortic stenosis, which currently afects 2% to 5% of adults over 65 years of age, has become a public health problem worldwide in recent decades. In Brazil, the prevalence of calcific aortic valve disease increased by 201.8% from 1990 to 2019, reflecting population aging.Transcatheter aortic valve implantation (TAVI) has appeared as an option to reduce mortality in patients with aortic stenosis in whom surgery would be difficult or risky.– Although several clinical studies have played an important role […]

Introduction Although evidence-based medicine (EBM) has contributed to establishing the foundations of patient care for over 40 years, scientific principles are still often disregarded in clinical decision-making. As a result, EBM may be mistakenly characterized as a barrier that limits the applicability of poorly recognized concepts, otherwise perceived as thoroughly supported by medical literature. The critical analysis of medical publications should not rely on methods estranged from the scientific realm, and EBM provides the means to limit such hazardous misconceptions. […]

Introduction Constrictive pericarditis is defined as an inflammatory process of the fibrous and serous layers of the pericardium that leads to pericardial thickening and compression of the cardiac chambers, ultimately resulting in a significant reduction in cardiac function. Tuberculous pericarditis remains the leading cause of constrictive pericarditis worldwide, especially in the remote rural areas of eastern countries where the level of health care and services is relatively backward. Other causes include postcardiotomy, connective tissue diseases, postmediastinal irradiation, uremia, and idiopathic. […]

Abstract A six-year-old girl with restrictive cardiomyopathy and hypertrabeculation, due to the early onset of her disease, whole exome sequencing was conducted, revealing the presence of a novel heterozygous missense variant in the FLNC gene. The same gene variant was also identified in her father, who, at an adult age, displayed normal imaging results and was symptom-free. This variant has not been reported in population databases or current medical literature and is classified as likely pathogenic.

Introduction Marfan syndrome (MS) is a systemic disease of the connective tissue with an autosomal dominant transmission, usually associated with a mutation in the fibrillin 1 gene (FBN1). The estimated prevalence is 6.5/100,000. According to the revised Ghent criteria, mutation in the FBN1 gene, lens ectopy, and aortic root dilation are the key factors for the diagnosis of MS., Life expectancy is essentially determined by cardiovascular complications, particularly aortopathy. […]

The recent update on the guideline for the management of cardiomyopathy in Chagas disease brings several significant improvements. The evidence on etiological stroke investigation, management of secondary prophylaxis, and overall epidemiology are all of vital importance for clinicians to improve treatment for these patients. One concern that arises from the guideline pertains to the indication of oral anticoagulation, particularly the suggestion that any previous ischemic stroke would warrant such intervention. […]

Arq Bras Cardiol. 2018; 110(1):44-51 In the Original Article “Melatonin-Induced Protective Effects on Cardiomyocytes Against Reperfusion Injury Partly Through Modulation of IP3R and SERCA2a Via Activation of ERK1”, with DOI: 10.5935/abc.20180008, published in the journal Arquivos Brasileiros de Cardiologia, Arq Bras Cardiol. 2018; 110(1):44-51, on page 49, correct Figure 5A to Figure 5A shown below. […]

Abstract Although the existing framework for classifying acute myocardial infarction (AMI) into STEMI and NSTEMI has been beneficial, it is now considered to be falling short in addressing the complexity of acute coronary syndromes. The study aims to scrutinize the current STEMI-NSTEMI paradigm and advocate for a more nuanced framework, termed as occlusion myocardial infarction (OMI) and non-occlusion myocardial infarction (NOMI), for a more accurate diagnosis and management of AMI. A comprehensive analysis of existing medical literature was conducted, with […]