Arq. Bras. Cardiol. 2022; 118(6): 1116-1117
Evaluation of Various Pathophysiological Pathways in the Prognosis of Heart Failure with Reduced Ejection Fraction: Seeing Beyond the Heart
João Marcos Barbosa-Ferreira
, Andreza Araújo de Oliveira
This Short Editorial is referred by the Research article "Albumin-Bilirubin Score to Predict Outcomes in Patients with Idiopathic Dilated Cardiomyopathy".
The manuscript “Albumin-bilirubin score to predict outcomes in patients with idiopathic dilated cardiomyopathy” provides an important way to assess the prognosis of patients with dilated cardiomyopathy (DCM) by demonstrating a higher rate of major adverse clinical events (MACEs) in patients with a higher score. Furthermore, this score works as an independent predictor of long-term mortality.
Heart Failure with reduced ejection fraction (HFrEF), often characterized as DCM, has its pathophysiological aspects closely related to its therapy and prognosis. The study of the pathophysiology of HFrEF is based on cardiovascular hemodynamic alterations and intense neurohumoral activation (mainly of the autonomic nervous system, renin-angiotensin-aldosterone system and natriuretic peptides system). These pathophysiological aspects are widely used in the therapy and prognostic assessment of patients with HFrEF.
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Keywords: Biomarkers; Heart failure; Prognosis
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