Arq. Bras. Cardiol. 2020; 115(5): 882-884
Lifestyle in the Very Elderly Matters
This Short Editorial is referred by the Research article "Association of Cardiovascular Risk Factors and APOE Polymorphism with Mortality in the Oldest Old: A 21-Year Cohort Study".
According to the estimates and projections of the 2019 Revision of World Population Prospects, life expectancy will continue to rise in the following 30 years worldwide, the percentage of the population aged 65 years or over will jump from 9% in 2020 to 16% in 2050, and the number of persons aged 80 years or over will triple up to 2050.
The biology of aging and implicated genes has been studied for a long time as a basis for the search for therapies that may mitigate age-related processes, such as dementia and cardiovascular disease. Among the multitude of aspects that have been explored, the research involving apolipoprotein E (apoE) assumes particular relevance. ApoE is a 299-amino acid protein mainly synthesized by the hepatocytes. Like any other apolipoprotein, apoE is a constituent of lipoproteins and, therefore, has a role in lipid metabolism. In the plasma, apoE is primarily carried by triglyceride-rich lipoproteins and mediates the clearance of their remnants by the low-density lipoprotein receptor. In the brain, in situ produced apoE acts on the redistribution of lipids to neurons, as well as in the clearance of β-amyloid, much known for its association with Alzheimer disease.,
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Keywords: Aging; Apolipoproteins E; Life Style
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