Arq. Bras. Cardiol. 2020; 115(5): 894-895
Pre-Clinical Meta-Analysis: Another Brick in the Wall
Amanda Gomes Pereira, André Monti Garzesi, Sergio Alberto Rupp Paiva
, Bertha Furlan Polegato
This Short Editorial is referred by the Research article "Aerobic Exercise and Cardiac Function of Murines Exposed to Doxorubicin: a Meta-Analysis".
Currently, systematic review and meta-analysis are considered level 1 of scientific evidence and it is widely used in epidemiology and evidence-based medicine. The term meta-analysis comes from the Greek and means “analysis of analyses”, referring to its definition “statistical analysis of a large collection of analysis results from individual studies for the purpose of integrating the findings” proposed by the statistician Gene V. Glass in 1976.
Despite the similarities, it is important to note that meta-analysis and systematic review are not synonymous. Meta-analysis is often, but not always, preceded by a systematic review, which aim to gather similar studies that meet the strict approach eligibility criteria in order to answer a specific research question, whereas meta-analysis integrates the results of included studies by statistical techniques.,
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