Arq. Bras. Cardiol. 2023; 120(6): e20230341
Scaffolds for Use in Blood Vessel Bioengineering: What are the Prospects?
Leonardo Rufino Garcia
, André Monti Garzesi, Flávio de Souza Brito
, Marcello Laneza Felicio, Matheus Bertanha
This Short Editorial is referred by the Research article "Decellularized Vascular Scaffolds Derived from Bovine Placenta Blood Vessels".
Cardiovascular diseases are currently the main causes of morbidity and mortality in Brazil and worldwide., Its treatment is multimodal and has as one of its targets the fight against the progression of its major pathophysiological substrate, atherosclerosis. Lifestyle changes, prescription and use of antiplatelet agents, anticoagulants, and hypolipidemic agents, treatment of comorbidities such as systemic arterial hypertension and diabetes mellitus, and even revascularization of target organs lato sensu are important in controlling its clinical evolution.
However, many patients still have an unfavorable evolution of atherosclerosis with only clinical management and become candidates for revascularization procedures. Thus, the availability of vascular substitutes for use as grafts is essential, which can be autologous or synthetic (artificial). In turn, endovascular techniques with stents can be used to treat stenoses or occlusions according to specific clinical indications.
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