Arq. Bras. Cardiol. 2022; 119(3): 446-447
Should We “Tweak” Our Approach to Coronary Artery Disease?
This Short Editorial is referred by the Research article "The Association of TWEAK with Coronary Artery Calcification in Patients with Chronic Kidney Disease".
Despite our great advances in medical technology, Cardiovascular Disease remains the leading cause of death worldwide. Coronary Artery Disease (CAD) is one of the hallmarks.
It is believed that the first correlation between coronary flow and angina pectoris was made by William Heberden in 1768, but its anatomical remarks were only described by 1829, when Jean Lobstein introduced the term Arteriosclerosis, reporting an abnormal formation in arterial walls. Later, in 1856, Rudolph Virchow suggested an arterial wall injury mechanism that could explain those findings from a cellular pathology compound. However, it was only until the 20thcentury, in the late 70´s, that the consortium of endothelial damage-wall shear stress-smooth muscle proliferation-thrombogenesis was first elucidated in the “Response to Injury Hypothesis” by Ross et al..
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