Arq. Bras. Cardiol. 2020; 115(1): 29-30
Targeting the Renin-Angiotensin-Aldosterone System in Obesity
Ariane Vieira Scarlatelli Macedo
This Short Editorial is referred by the Research article "AT1Receptor Blockade Improves Myocardial Functional Performance in Obesity".
Short Editorial related to the article: AT1Receptor Blockade Improves Myocardial Functional Performance in Obesity
Obesity has been increasing across the globe and markedly raising the prevalence of cardiovascular diseases (CVD). Obesity, particularly severe obesity, causes hemodynamic alterations that contribute to changing cardiac morphology, which may predispose to impaired ventricular function and heart failure. These alterations include a high cardiac output state in most cases, as well as left ventricular hypertrophy (LVH) and left ventricular (LV) diastolic dysfunction. Experimental studies and some investigations on humans propose that specific neurohormonal and metabolic alterations generally associated with obesity may lead to changes in cardiac structure and function.
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