Infecção por COVID-19 em Gestante Cardiopata

Introducao Sobre os aspectos obstetricos da infeccao COVID-19, e necessario considerar que ela e uma doenca recente, nao havendo conhecimento especifico acerca do assunto para a elaboracao de protocolos assistenciais. Em decorrencia disso, varias orientacoes baseiam-se na comparacao com infeccoes causadas por outros virus (SARS-CoV, MERS-CoV e H1N1); portanto, tudo o que existe de evidencias atualmente esta sujeito a modificacoes a partir de novas descobertas. As infeccoes causadas por SARS-CoV e MERS-CoV foram limitadas regionalmente, mas os poucos casos obstetricos [...]


Introduction
Regarding the obstetric aspects of COVID-19 infection, one should consider that it is a recent disease, with no specific knowledge on the theme to draft medical care protocols.For this reason, various guidelines are based on its comparison with infections caused by other viruses (SARS-CoV, MERS-CoV, and H1N1); therefore, all information concerning current evidence on the issue is subject to change due to new discoveries.
Infections caused by SARS-CoV and MERS-CoV have tended to be regionally bound, but the few obstetric cases published in the literature point to the need for advanced medical support for pregnant women with severe involvements identified in maternal prognoses.[3][4] In a recently published literature review, 23 studies were selected, including 32 pregnant women and 30 newborns.The pregnant women were asymptomatic in 22% of the cases, but 6% required advanced life support medical care in an Intensive Care Unit (ICU).Births were performed through Caesarean section (C-section) in 27 women, and 47% of the births occurred before 36 weeks of gestation.The authors informed that no case of maternal death was observed in this review.Likewise, another extensive literature review pointed out that, to date, no case of the vertical transmission of this virus has been confirmed. 5se series on the impact of Coronavirus during pregnancy are scarce in the literature.In women affected by severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS), the mortality rate proved to be higher in those affected during pregnancy, as compared to those women who were not pregnant. 6

Description
This study examines a 26-year-old, pregnant woman, G3P1A1, with a medical history of rheumatic mitral valve disease, who underwent a biological mitral valve replacement nine years ago.This patient presented a medical history of previous hospitalizations, in 2014, for a C-section, pre-term birth.At that moment, the patient was asymptomatic, from the cardiovascular point of view, and for this reason, there was no recommendation of a definitive contraception prescribed by the team that evaluated the patient.
On October 31, 2019, the woman required hospitalization, and received medical care at the cardiologic emergency clinic due to a new 16-week gestational condition, evolving to sustained ventricular tachycardia, with a heart rate of 140 beats per minute (BPM), blood pressure of 120 x 70 mmHg, with no clinical signs of hemodynamic instability.
The result of the laboratory exams on the day of hospitalization showed no signs of anemia, coagulation disorders, infection, hydro-electrolyte imbalance, or hepatic or renal dysfunction.In an obstetric ultrasound (US) of a single fetus, no signs of fetal distress were observed.
After compensating for both the arrhythmia and the clinical condition, the pregnant woman remained in the hospital, receiving medical care from the obstetrics team and evaluation from the cardiology team.She was submitted to an echocardiogram, which showed evidence of a swollen left atrium (50mm), an ejection fraction of 64%, a prosthesis valve area of 1.0 cm 2 , a left ventricle-left atrium (LV-LA) gradient of 12 and a pulmonary artery systolic blood pressure of 40.The patient received hospital discharge on November 5, 2019, with the medical advice to continue in outpatient follow-up for high-risk pre-natal care.
Nonetheless, on November 9, 2020, the patient was once again admitted to the emergency clinic, with a medical condition of tachycardia, with a heart rate of 200 BPM and lower abdominal pain.The electrocardiogram revealed paroxysmal supraventricular tachycardia.
On that date, the patient's physical exam, of 33 weeks and 5 days, showed no change in pulmonary auscultation, with no signs of hemodynamic instability, with eupnea in ambient air, a uterine height of 33 cm, a fetal heartbeat of 129 BPM, a closed posterior and thick cervix, with no gynecological losses or signs of bleeding.After the clinical measures, she returned to the sinus rhythm and was referred to the obstetric infirmary, where she remained in follow-up with the obstetrics team and was evaluated by the cardiology team.The cardiology team recommended choosing the birth time according to the criteria established by the obstetrics team and through a C-section, with subsequent sterilization due to the patient´s cardiovascular risk.This team also recommended the use of cardiac glycosides should a new event of tachycardia occur.Thus, the patient received hospital discharge on March 23, 2020, with a prescription of carvedilol, 3.125 mg 12/12 h and AAS, 100 mg/day, as well as the continuance of Benzathine Penicillin G, every 21 days.
On March 30, 2020, the patient, now at 36 weeks and 5 days of gestation, was admitted to the cardiovascular emergency clinic at Fundação Hospital de Clínicas Gaspar Vianna (FHCGV), with a fever, a productive cough, and severe respiratory insufficiency.The physical exam showed evidence of tachypnea in ambient air, with a blood pressure of 100 x 70 mmHg, and pulmonary auscultation with an audible vesicular murmur with diffuse rumbles.
Tomography of the patient's chest, with apex portion with evidence of diffuse ground glass, peripheral predominance and bilateral pleural effusion (figure 1), in addition to 1/3 medium with evidence of diffuse ground glass, also peripheral and bilateral pleural effusion (figure 2 ).
An orotracheal intubation was performed, placed under controlled blood pressure, positive end expiratory pressure (PEEP) 9, respiratory rate of 20 irpm, tidal volume of 300, fraction of inspired oxygen (FiO) of 30%, with a PO 2 /FiO 2 relation of 388.Nasopharyngeal and oral swabs were also collected, and a PCR was performed to detect COVID-19 and H1N1.Later, the patient was referred for a C-section and urgent sterilization.The surgery was performed under general anesthesia.
After the operation, the patient was sent to the ICU, remaining sedated, considering a -5 Rass scale.She evolved with hemodynamic instability and a capillary refill time of more than 2 seconds, requiring the introduction of vasoactive substances (norepinephrine and dobutamine).The following prescription was then begun: olsetamivir, 75 mg 12/12 h; azithromycin, 500 mg/day; hydroxychloroquine, 400 mg 12/12 h; piperacillin-tazobactam, 4.5 g 6/6 h; furosemide, 2 ampoules 8/8 h; carbegoline in a single dose to inhibit lactation; and prophylaxis for pulmonary thromboembolism (PTE) with enoxaparin, 40 mg/day.After the birth, a chest X-ray was performed, which showed the presence of consolidation, standard air bronchogram in a ground-glass pattern in the bilateral superior lobes, with discrete bilateral pleural effusion.
On April 1, 2020, the patient showed clinical improvement, hemodynamic stability, with the possibility to suspend the vasoactive drugs, still under mechanical ventilation, but now on pressure support, presenting an increase in the PO 2 /FiO 2 relation of 644.Sedation was paused in the morning.
On the same day, the PCR exam for COVID-19 was positive.On April 2, 2020, the patient was transferred to the Fundação Santa Casa de Misericórdia do Pará, a reference service for the handling of COVID-19 patients.There, the patient underwent treatment with olsetamivir, 150 mg/day, chloroquine diphosphate, 450 mg/day; azithromycin, 500 mg/day; and piperacillin-tazobactam, 18 g/day.On April 4, 2020, she evolved to a supraventricular tachyarrhythmia, and on April 7 th , she presented acute respiratory failure, again requiring invasive mechanical ventilation, in addition to sedation and curarization.
The patient was placed in pronation on April 9, 2020, for 16 hours, but the ventilatory asynchrony and a low PO 2 / FiO 2 relation were maintained, even after high PEEP and FiO 2 levels.On April 11, 2020, the patient was kept on ventilatory asynchrony, SatO 2 of 50%, and a low PO 2 /FiO 2 relation.She then evolved to a cardiac arrest with asystole, with an unsuccessful attempt to revive the patient, who died at 10:10am.
The newborn was born in bradycardia and fetal distress, requiring resuscitation; Apgar 2/6/7, clear and smooth amniotic liquid, with a birth weight of 2.750 kg, birth length of 50 cm, cephalic, thoracic, and abdominal perimeter de 34,

Figure 1 -
Figure 1 -Patient's chest X-ray, portion of the apex with evidence of a diffuse ground-glass pattern, peripheral predominance, and bilateral pleural effusion.